The Laughlin Lab
Chemical Biology
& Neuroscience
30. Kumar, P., Huang, W., Shukhman, D., Camarda, F. M. & Laughlin, S. T.
Stable cyclopropene-containing analogs of the amino acid neurotransmitter glutamate.
Tetrahedron Lett., 2019, 60, 22, 1476–1480
29. Yin, X., Hewitt, D. R. O., Preston, A. N., Heroux, L. A., Agamalian, M. M., Quah, S. P., Zheng, B., Smith, A. J., Laughlin, S. T., Grubbs, R. B. & Bhatia, S. R.
Hierarchical assembly in PLA-PEO-PLA hydrogels with crystalline domains and effect of block stereochemistry.
Colloids and Surfaces B: Biointerfaces, 2019, 180, 102–109
28. Kumar, P., Zainul, O., Camarda, F. M., Jiang, T., Mannone, J. A., Huang, W. & Laughlin, S. T.
Caged cyclopropenes with improved tetrazine ligation kinetics.
Org. Lett., 2019, 21, 10, 3721–3725
27. Jiang, T., Kumar, P., Huang, W., Kao, W.-S., Thompson, A.O., Camarda, F.M. & Laughlin, S. T.
Modular enzyme- and light-based activation of the cyclopropene-tetrazine ligation.
26. O'Neill, B. O., Eckartt, K. & Laughlin, S. T.
Chemogenetic and optogenetic strategies for spatiotemporal control of split-enzyme-based calcium recording.
In Revision
25. Anh, S. H., Thach, D., Vaughn, B. A., Alford, V. M., Preston, A. N., Laughlin, S. T. & Boros, E.
Linear Desferrichrome-linked silicon-rhodamine antibody conjugate enables targeted multimodal imaging of HER2 in vitro and in vivo.
Mol. Pharm., 2019, 16, 1412–1420
24. Preston, A. N., Farr, J. D., Tan, K. C., Cervasio, D. A., Butkus, L. R. & Laughlin, S. T.
Design principles for cationic, astrocyte-targeted probes.
ChemBioChem, 2019, 20, 366–370
23. Kumar, P. & Laughlin, S. T.
Modular activatable bioorthogonal reagents.
Methods in Enzymology, 2019, 622, 153–182
22. Preston, A. N., Cervasio, D. A. & Laughlin, S. T.
Visualizing the brain's astrocytes.
Methods in Enzymology, 2019, 622, 129–151
21. Kumar, P. , Jiang, T., Zainul, O., Preston, A. N., Li, S., Farr, J. D., Suri, P. & Laughlin, S. T.
Lipidated cyclopropenes via a stable 3N-spirocyclopropene scaffold.
Tetrahedron Lett., 2018, 59, 37, 3435–3438
20. Preston, A. N., Farr, J. D., O'Neill, B. K. & Laughlin, S. T.
Visualizing the brain's astrocytes with diverse chemical scaffolds.
ACS Chem. Biol., 2018, 13, 1493–1498
19. Kumar, P.*, Jiang, T.*, Li, S., Zainul, O. & Laughlin, S. T.
Caged cyclopropenes for controlling bioorthogonal reactivity.
Org. Biomol. Chem., 2018, 16, 4081–4085
*Denotes equal contribution.
18. O'Neill, B. K. & Laughlin, S. T.
Neuronal calcium recording with and engineered TEV protease.
ACS Chem. Biol., 2018, 13, 1159–1164
17. Kumar, P., Zainul, O. & Laughlin, S. T.
Inexpensive multigram-scale synthesis of cyclic enamines and 3-N spirocyclopropyl systems.
Org. Biomol. Chem., 2018, 16, 652–656
16. Quah, S. P., Smith, A. J., Preston, A. N., Laughlin, S. T. & Bhatia, S. R.
Large-area alginate/PEO-PPO-PEO hydrogels with thermoreversible rheology at physiological temperatures.
15. Kumar, P., Shukhman, D. & Laughlin, S.T.
A photocaged, cyclopropene-containing analog of the amino acid neurotransmitter glutamate.
Tetrahedron Lett., 2016, 57, 5750–2
14. Shah, L., Laughlin, S.T. & Carrico, I.S.
Light-Activated Staudinger-Bertozzi Ligation within Living Animals.
J. Am. Chem. Soc., 2016, 138, 5186–9
Prior to Stony Brook
13. Dehnert, K.W., Baskin, J.M., Laughlin, S.T., Beahm, B.J., Naidu, N.N., Amacher, S.L. & Bertozzi, C.R.
Imaging the sialome during zebrafish development with copper-free click chemistry.
12. Dehnert, K.W., Beahm, B.J., Huynh, T.T., Baskin, J.M., Laughlin, S.T., Wang, W., Wu, P., Amacher, S.L. & Bertozzi, C.R.
Metabolic labeling of fucosylated glycans in developing zebrafish.
ACS Chem. Biol., 2011, 6, 547–52
11. Baskin, J.M.*, Dehnert, K.W.*, Laughlin, S.T.*, Amacher, S.L. & Bertozzi, C.R.
Visualizing enveloping layer glycans during zebrafish early embryogenesis.
Proc. Natl Acad. Sci. U.S.A., 2010, 107, 10360–5
*These authors contributed equally to this work.
10. Laughlin, S.T. & Bertozzi, C.R.
In vivo imaging of Caenorhabditis elegans glycans.
ACS Chem. Biol., 2009, 4, 1068–72
9. Laughlin, S.T. & Bertozzi, C.R.
Imaging the glycome.
Proc. Natl Acad. Sci. U.S.A., 2009, 106, 12–7
8. Czlapinski, J.L., Schelle, M.W., Miller, L.W., Laughlin, S.T., Kohler, J. J., Cornish, V. & Bertozzi, C. R.
Conditional glycosylation in eukaryotic cells using a biocompatible chemical inducer of dimerization.
J. Am. Chem. Soc., 2008, 130, 13186–7
7. Laughlin, S.T., Baskin, J.M., Amacher, S.L. & Bertozzi, C.R.
In vivo imaging of membrane‐associated glycans in developing zebrafish.
6. Laughlin, S.T. & Bertozzi, C.R.
Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics.
Nat. Protoc., 2007, 11, 2930–44
5. Baskin, J.M., Prescher, J.A., Laughlin, S.T., Agard, N.J., Chang, P.V., Miller, I.A. & Bertozzi, C.R.
Copper‐free click chemistry for covalent labeling in living systems.
Proc. Natl Acad. Sci. U.S.A., 2007, 104, 16793–97
4. Rabuka, D.R., Hubbard, S.C., Laughlin, S.T., Argade, S.P. & Bertozzi, C.R.
A chemical reporter strategy to probe glycoprotein fucosylation.
J. Am. Chem. Soc., 2006, 128, 12078–79
3. Laughlin, S.T., Agard, N.J., Baskin, J.M., Carrico, I.S., Chang, P.V., Ganjuli, A.S., Hangauer, M.J., Lo, A., Prescher, J.A. & Bertozzi, C.R.
Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics.
Meth. Enzymol., 2006, 415, 230–250
2. de Graffenried, C.L., Laughlin, S.T., Kohler, J.J. & Bertozzi, C.R.
A small‐molecule switch for Golgi sulfotransferases.
Proc. Natl Acad. Sci. U.S.A., 2004, 101, 16715–20
1. Kohler, J.J., Czlapinski, J.L., Laughlin, S.T., Schelle, M.W., de Graffenried, C.L. & Bertozzi, C.R.
Directing flux in glycan biosynthetic pathways with a small molecule switch.